Fumonisin B1 Concentrations in Feeds from 45 Confirmed Equine Leukoencephalomalacia Cases

Eqüine leukoencephalomalacia and Fumonisin B

This article describes clinical, etiologic and pathologic diagnosis of an outbreak of equine leukoencephalomalacia. Two samples of the corn consumed by the affected horses contained fumonisin B 1 at levels of 46 and 53 μg/g and Fusarium moniliforme, a good in vitro mycotoxin producer.

Leukoencephalomalacia in a horse induced by fumonisin B1 isolated from Fusarium moniliforme.

Each of two horses was dosed by stomach tube with culture material on maize of Fusarium moniliforme MRC 826. One horse developed severe hepatosis and mild oedema of the brain after 6 doses of 2.5 g of culture material/kg body mass/day in 7 days. The second horse, in a similar experiment but at a dosage rate of 1.25 g/kg/day, developed mild hepatosis and moderate oedema of the brain. In both ani...

Leukoencephalomalacia in two horses induced by oral dosing of fumonisin B1.

Leukoencephalomalacia (LEM) was induced by the oral administration of fumonisin B1 (FB1) to 2 horses: a filly received 59.5 mg/kg of a 50% preparation of FB1, administered in 21 doses of 1.25-4 mg/kg over 33 days; a colt, 44.3 mg/kg of 95% pure FB1 in 20 doses of 1-4 mg/kg in 29 days. Both animals developed nervous signs such as apathy, changes in temperament, inco-ordination, walking into obje...

The Health and Toxic Adverse Effects of Fusarium Fungal Mycotoxin, Fumonisins, on Human Population

Problem statements: Fumonisin was a mycotoxin produced mainly by fungi belonging to the genus Fusarium in various foods and feeds. They occurred worldwide and were found predominantly in corn and in corn-based animal feeds and also can be found in other crops. Contamination of food and feed with fumonisins has been implicated in and associated with a number of diseases in both livestock as well...

NATIONAL TOXICOLOGY PROGRAM EXECUTIVE SUMMARY OF SAFETY AND TOXICITY INFORMATION FUMONISIN CAS Number 116355-83-0 Fumonisin B1 Fumonisin B2 Fumonisin B3 Fumonisin B4 Fumonisin A1 Fumonisin